MicroRNA-144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3
نویسندگان
چکیده
منابع مشابه
MicroRNA‑144 suppresses tumorigenesis of hepatocellular carcinoma by targeting AKT3.
Aberrant expression of microRNAs (miRNAs) has been shown to be associated with the progression and metastasis of cancer. Dysregulation of miR‑144 has been observed in numerous types of cancer; however, the exact role of miR‑144 in hepatocellular carcinoma (HCC) remains unclear. The present study observed that miR‑144 was downregulated in HCC tissues and cell lines. Forced overexpression of miR‑...
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MicroRNAs (miRNAs) have been implicated in the orchestration of diverse cellular processes including differentiation, proliferation, and apoptosis and are believed to play pivotal roles as oncogenes and tumor suppressors. miR-122, a liver specific miRNA, is significantly down-regulated in most hepatocellular carcinomas (HCCs) but its role in tumorigenesis remains poorly understood. Here we iden...
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In our previous studies, the Illumine Soledad massively parallel signature sequencing of miRNomes in non‑tumor and hepatocellular carcinoma (HCC) tissues revealed that microRNA (miR)-144-3p was significantly downregulated in HCC, but its role in HCC development, especially angiogenesis, remains unclear. In this investigation, we found recovering miR‑144‑3p expression can significantly suppress ...
متن کاملRetraction: miR-122 Regulates Tumorigenesis in Hepatocellular Carcinoma by Targeting AKT3
A Pfizer representative contacted the editorial office to raise concerns that there are image duplications in this article. Pfizer has undertaken a review and determined that there are duplications in Fig 4A of the article and that part of the experiments cannot be verified. In light of the concerns identified, the authors and the PLOS ONE Editors retract this article. We did not receive any co...
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BACKGROUND/AIM Increasing evidence show microRNAs (miRNAs) are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role of miR-144 in HCC, as well as to identify its underlying mechanism. METHODS The expression levels of miR-144 were assessed in multiple HCC cell lines, as well as in liver tissues from patients with HCC. We further examined the effects of m...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2014
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2014.2844